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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

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With a better molecular understanding of such specific mechanisms, adjunctive therapies can be developed for a combination treatment strategy, as is the standard approach for many other diseases

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