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While that gap is meaningful, it was not dramatic enough for AOD-9604 to win approval as a standalone obesity drug, and formal development was paused in 2007
Fu, C., Cheuk, C., Chiu, Y

Zheng YY, Ma YT, Zhang JY, et al

Aurum, Bielefeld Said HM (1999) Biotin bioavailability and estimated average requirement: why bother
