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TLK199Ezatiostat (TER199 free base
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Third, because the number of wild-type mtDNA molecules is key for healthy physiology, it is tempting to speculate that individuals with a higher mtCN polygenic score may be more resilient to pathogenic, heteroplasmic mtDNA mutations, helping to explain some of the striking phenotypic variability observed between family members that carry the same maternally transmitted pathogenic mtDNA mutations 47
doi: 10.1126/science.aai8515 154 ReiterJGHungWTLeeIHNagpalSGiuntaPDegnerSet al
