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Preclinical studies in rodents have shown an association between GLP-1 receptor activation and thyroid C-cell changes, although a direct causal link in humans has not been established, and UK/EU SmPCs for authorised GLP-1 RAs do not list MTC or MEN2 as a formal contraindication
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Besides, the protein levels of progerin and Lamin A/C in primary rat hepatocytes were constantly upregulated, confirming hepatocyte premature senility in CCl 4 -induced acute and chronic liver injury (Supplementary Fig
doi: 10.1136/annrheumdis-2013-204441
