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Description
The biggest problem is shrinkage of the brain cells, which causes confusion, coma, and eventually rupture of blood vessels that connect the brain to the cranium
However, intranasal administration is also considered an efficient route for systemic effects due to the dense vasculature of the nasal mucosa
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Systemic effects tend to be mild and transient: headaches, nausea, dizziness, facial flushing, and drowsiness during the initial weeks as the body adjusts
