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melanotic macule inside cheek Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown Melanotic macule detected in the
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Carnitine may have some acute benefits related to fat oxidation

This can make lips look darker or uneven

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These findings suggest that both LXR activation and repression can influence tumor progression