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10.1038/s41574-023-00898-1 [DOI] [PubMed] [Google Scholar] 39.Zhang Y, Qian B, Yang Y et al (2024) Visceral adipocyte-derived extracellular vesicle miR-27a-5p elicits glucose intolerance by inhibiting pancreatic -cell insulin secretion
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Lipolysis may achieve the right lipophilicity for the drug to cross the BBB, and either insufficient or too much lipolysis will affect the penetration rate of the drug
