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As the pathological burden increases, this metabolic dysregulation may eventually evolve into hepatic fibrosis, cirrhosis, or even further development of hepatocellular carcinoma [75]

Clinical Research Findings: SUSTAIN and PIONEER Trials A comprehensive safety analysis of 11,159 patients with type 2 diabetes across the SUSTAIN and PIONEER phase IIIa clinical trial programs found that gastrointestinal disorders occurred in 41.9% of patients receiving subcutaneous semaglutide and 39.1% receiving oral semaglutide, compared to 22.0% and 24.8% in comparator groups, respectively

This hormone helps boost insulin secretion (when glucose levels are high) and insulin sensitivity, enhances fat metabolism, and improves energy balance, leading to greater weight loss than single receptor drugs such as semaglutide (Ozempic and Wegovy), liraglutide, and dulaglutide

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