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This mechanism, described as the nosebrain axis, is associated with the anatomical proximity of the olfactory epithelium and CNS structures, and with transport along the pathways of the olfactory and trigeminal nerves

The dihydropyridine L-type calcium channel blocker Isradipine has been reported to reduce hypoxia-induced activation of Ca 2+ -dependent xanthine oxidases, monoamine oxidases, cytosolic phospholipase A 2 , and cyclo-oxygenases (COX-2) along with a decrease in free radical generation and cytochrome- c release (Barhwal et al., 1991) was also inhibited by Isradipine

Monitoring by a healthcare professional is recommended to avoid toxicity and ensure the right doses are taken
