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Both come from the same generation of synthetic secretagogues discovered by Cyril Bowers team and act through the same receptor, yet they differ in profile enough that in the literature and in reagent catalogues they function as distinct compounds

This finding led to its investigation in biomarker selected NRF2-active tumors

The antioxidant defence systems include enzymes that contribute to the ascorbate glutathione cycle such as dehydroascorbate reductase (DHAR), ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR) and glutathione reductase (GR), which together with other enzymes such as superoxide dismutase (SOD) and catalase (CAT) play a main role in the reduction of ROS production [44]

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