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10.1016/j.celrep.2021.109235 148 XuX.LaiY.HuaZ

TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury

Some of the roles that cyanocobalamin serves in the body include: Cofactor for methionine synthase and L-methymalonyl-CoA mutase
Hypoxia resulting from lung injury triggers hypoxia-inducible factor-1 (HIF-1), which upregulates endothelin-1, further constricting pulmonary vessels and stressing the RV