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While stress is a main component of a suppressed immune system there are plenty of other factors that influence the lining of the gut itself - factors such as prolonged exposure to antibiotics, inflammatory foods, toxins, etc
Sasaki K, Jabbour E, Cortes J, Kadia T, Garcia-Manero G, Borthakur G , Jain P, Pierce S, Daver N, Takahashi K, O'Brien S, Kantarjian H, Ravandi F

20 In recent years, multiple X-ray and electron microscopy structures of these megasynthases have been elucidated, 621626 and together with modern bioinformatics and machine learning approaches, have enabled transformative approaches to reenergize pursuits of PKS and NRPS engineering

doi: 10.1016/j.freeradbiomed.2004.03.016
