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Previous mechanistic studies have demonstrated a significant association between citrate accumulation and lifespan extension with elevated citrate levels being consistently observed in aging model organisms

Ferrer M, Mndez-Garca C, Rojo D, Barbas C, Moya A

We first examined the concentration-dependent effect of PFOS on mitochondrial bioenergetics and discovered that an increase in the PFOS concentration from 100 to 200 M significantly decreased mitochondrial bioenergetics, as evidenced by the decreased ATP production, maximal respiration and spare respiratory capacity, and increased proton leakage (Fig

doi: 10.1073/pnas.1221655110 103 JiXWuLMarionTLuoY