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Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

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Synthetic tetrapeptide (Ala-Glu-Asp-Gly) small, chemically defined, amenable to standard analytical frameworks Studied for hTERT upregulation in human fibroblast cell culture models published in peer-reviewed literature Research tool for telomerase enzyme activity assays, TRAP assays, and telomere length measurement studies Studied in bovine cumulus cell and cumulus-oocyte complex models for telomerase activity published in PMC Examined for DNA binding interactions with specific ATTTG sequence motifs in structural biology research Referenced in over 100 publications primarily from the St