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recently demonstrated that overexpression of DNMT3A in rats leads to variation of gene expression, specifically within the brain and testis [54]

Nonlinearity Biol Toxicol Med

doi: 10.1016/S0361-9230(97)00441-3

However, there are obvious limitations in the evaluation of the results of combination therapy in current clinical practice, which focuses excessively on the improvement of disease status, such as tumor size and prolonged survival, while neglecting other crucial evaluation indices
