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Moreover, they can be further categorized into various groups based on their properties, origins, and mechanisms of action (Fig

doi: 10.1177/15563316251355551

But biology is rarely that simple

Studies have shown that A1AR activation upregulates the protective factor IL-11 through activation of ERK and hypoxia-inducible factor 1-, as well as induces cytoprotective heat shock protein 27 (HSP27) synthesis through p38 MAPK activation phosphorylation, thereby reducing renal tubular apoptosis and inflammation [51]
