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In mice, estrogen receptors are predominantly expressed in the SCN shell in females, which regulates the pace of the clock, whereas androgen receptors (AR) are more prevalent in the core in males, rich in vasoactive intestinal peptide (VIP) neurons, which regulate the phase of the clock 70,90,91

Therefore, the credibility of all findings in the BPC 157 therapy story [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40] is tightly dependent on the relevance and general accuracy of the grand concepts of Robert and Szabo cytoprotection/organoprotection [41,42,43,44,45,46,47,48,49]

Al-Sawaf O, Clarner T, Fragoulis A, Kan YW, Pufe T, Streetz K, Wruck CJ (2015) Nrf2 in health and disease: current and future clinical implications

Changes in the gut microbiome on ketogenic diets also affect the levels of microbial-associated gamma-glutamylated metabolites that enter systemic circulation, resulting in an elevated brain GABA/glutamate ratio and suppression of epilepsy in mouse models [65]