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On December 7, 2021, she developed Grade IV myelosuppression, prompting a regimen adjustment to doxorubicin + bevacizumab until December 29, 2021, with no other significant adverse events

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Furthermore, it remains to be assessed whether LC supplementation, even that of short duration, may induce modifications, that can be preserved in the long term

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All these mechanisms synergistically induce or aggravate neuronal damage [62]

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