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Studies have shown that ROS affect multiple inflammatory signaling pathways, including the nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome signaling pathway, NF-B signaling pathway, and MAPK signaling pathway (Fig

A negative regulatory effect of TXNIP on tumor cells has been reported in several cancer types, including hepatocellular carcinoma and bladder cancer (17,18)

Significantly, BPA can activate these pathways at concentrations far below (pM - nM range) 60 those required for nuclear ER binding 63 and activation 64