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However, excessive amounts of fat-stored nutrients are released into the bloodstream to be absorbed by the body

This dual action, increasing fat breakdown while blocking fat formation, creates a metabolic environment that favors net fat loss even when caloric intake is not dramatically reduced

A few years later, the field exploded with a variety of medications for arthritis, lupus and all rheumatologic illnesses

observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )