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The label recommends IM injection twice weekly at 3 mL per 100 kg bodyweight (around 15 mL for a 500 kg horse), with the final dose given 46 hours before hard or fast work

Although the pharmacology of VPA is still not understood completely, the drug seems to enhance activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), impair activity of the excitatory neurotransmitter glutamate, and block sodium channels

Paper presented at the Seminars in hearing

Additionally, IL-1 and TNF- stimulate the enhanced production of inflammatory cytokines in eye-infiltrated immune cells, creating a positive inflammatory loop that leads to the progression of DED [16,49]