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Although these alterations are not specific for CD and may merely depend on mucosal inflammation, tight junctions' abnormalities have been found even in asymptomatic and first-degree relatives of CD patients, thus underlying a possible genetic background for permeability defects in CD (267)

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CagriSema Storage & Handling Storage Reference Lyophilized (powder form) Cagrilintide -4F (-20C) long-term Semaglutide -4F (-20C) long-term Pre-blended CagriSema -4F (-20C) long-term Reconstituted (liquid form) Cagrilintide 35.646.4F (28C) Semaglutide 35.646.4F (28C) Pre-blended CagriSema 35.646.4F (28C) Appearance Cagrilintide Clear after reconstitution Semaglutide Clear after reconstitution Pre-blended CagriSema Clear after reconstitution Stability window after reconstitution Cagrilintide Up to ~28 days refrigerated Semaglutide Up to ~28 days refrigerated Pre-blended CagriSema Per supplier COA Always defer to the supplier's specific stability window

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