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I think we can safely say the overwhelming answer would be (b)
doi: 10.3390/ijms21239234 39 SarkarALehtoSMHartySDinanTGCryanJFBurnetPW
Mutations in IDO2 are common in the population, but the elevation in tryptophan, likely triggered by multiple factors such as stressors and pathogens, is rarer and is the potential cause of ME/CFS
