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In this context, autophagy, a cellular process that enables cells to remove damaged organelles timely and provide energy for normal functions, emerges as a critical player [5]
Molecular Cloning: A Laboratory Manual , 3rd ed

However, the enzyme was also found to be active in the cytosolic and mitochondrial fractions

In a two-year study of 218 healthy adults, the calorie-restricted adults, those who restricted calories also experienced a 0.6 unit reduction in WBCs
