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A related glutaminase synthase inhibitor, IACS-6274, demonstrated clinical efficacy in overcoming cisplatin-resistance in an NRF2-active HNSCC xenograft model [85]

CYP2E1 and ALDH enzymatic activity CYP2E1 activity was assessed by measuring the rate of oxidation of p -nitrophenol (PNP) to p -nitrocatechol as described 54

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