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[DOI] [PubMed] [Google Scholar] 231.Miller J.W., Selhub J., Nadeau M.R., Thomas C.A., Feldman R.G., Wolf P.A

As we age, our increased susceptibility to disease may partially be attributed to genetic and epigenetic changes that develop over time with continual environmental exposure and damage from endogenous and exogenous reactive oxygen species (ROS)

Maternal diabetes induces autism-like behavior by hyperglycemia-mediated persistent oxidative stress and suppression of superoxide dismutase 2

This is not surprising since although metformin is the primary biguanide used in the treatment of T2DM, both phenformin and buformin have been demonstrated to negatively affect vitamin B 12 levels
