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Subcellular localization of AC5 and AC6 GPCR signaling pathways are type-specific for either AC5 or AC6, as determined by the colocalization of receptors and AC isoforms in lipid raft or non-raft plasma membranes (Ostrom et al., 2000)

PMID: 31574939

However, in Nfs1-suppressed mice we did not observe differences in red blood cell (RBC), basophil, eosinophil, or monocyte counts, hemoglobin, RBC distribution, mean cell hemoglobin concentration, or mean RBC volume, but a progressive increase in the ratio of total neutrophils to lymphocytes was observed over time (Fig S1A-B)

Dosing, Routes of Administration, and Protocols Disclaimer: The following dosing information is drawn from published preclinical research and emerging clinical use patterns