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Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence
Reported plasma levels of phenformin after 50-100 mg of phenformin uptake in patients are ~1.7 M 67 , while tissue concentrations have not been assessed but are expected to be much higher as reported in animal models 68

A subset of peptides, however, have amino acid sequences that make them hydrophobic or prone to aggregation at neutral pH
