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A total of 50 participants (men and women, 3560 years of age) with dry skin, skin moisture content of 49% or less, or crows feet greater than grade 3 were tested for 12 weeks in this double-blind, randomized, parallel, placebo-controlled study (equal numbers of subjects were in the APCP or placebo groups)

doi: 10.1016/j.neuint.2005.12.037 99

And therapeutic effect was related to the regulation of the TLR4/NF-B and TGF-1/Smad signaling pathways

In a mechanistic study with different types of tumour cell lines, the silencing of Grx1 activated the p53 signalling pathway, causing the cell cycle to stop in G1 causing senescence [188], which supported the idea that antioxidant systems, including Grx1, get upregulated in tumour cells as survival mechanism to counteract the high amount of ROS due to the changes in metabolism