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Loss of RB inhibits glucose oxidation by directly inducing the expression of a glucose homeostasis sensor and modulator pyruvate dehydrogenase kinase 4 [141], promotes glutamine uptake via increased expression of the glutamine transporter and GLS1, perturbing redox homeostasis by reducing GSH levels [142]

Present practice is informed by animal studies, off-label veterinary guidelines, and clinical experience, thus treatment must be under veterinary guidance, always

Second, the implanted cells not only release ideal and desired trophic factors for supporting RGCs, but they may also secret other agents that could be potentially detrimental to the microenvironment of RGC [123]

W badaniach tkanek mikkich ta kombinacja jest uwaana za zoty standard