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Moreover, ACNs have been shown to preserve the extracellular matrix (ECM) by inhibiting matrix metalloproteinases (MMPs), thereby slowing collagen degradation to protect vascular and dermal tissue

Importantly, these phase-dependent metabolic responses do not occur in isolation but are modulated by interacting physiological systems, including inflammation, the gut microbiota, circadian rhythms, physical activity, and behavioral factors [9,10,11,12,13,14]

[DOI] [PubMed] [Google Scholar] 157.Ale M.T., Mikkelsen J.D., Meyer A.S

[PubMed] [Google Scholar] 95.Martins V.D., Manfredini V., Peralba M.C., Benfato M.S