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Lower systemic inflammation can lead to clearer skin and better tone

doi: 10.1046/J.1600-079X.2003.00092.X 313 HardelandR

Additionally, macrophages exhibit synergistic characteristics of dynamic phenotypic conversion and functional remodeling in response to DAMPs: during the acute injury phase, DAMPs (such as high-mobility group box protein B1 and adenosine triphosphate) activate the Toll-like receptor 4/P2X7 receptor pathway, which in turn activates the NF-B and NLRP3 inflammasome, driving macrophages toward M1 polarization and the secretion of pro-inflammatory factors such as interleukin-1(IL-1) and tumor necrosis factor- (TNF-), thereby establishing an efficient pathogen clearance mechanism (Gong et al., 2020) (193)

Gheorghe et al., 2022)