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Description
No evidence supports its use over or in addition to evidence-based orthobiologic interventions
There are only few case reports where vitamin B12 deficiency was solely attributed as the cause of pyrexia.[2,3,4] The exact cause of pyrexia in megaloblastic anemia is not known but a proposed mechanism is that megaloblastic anemia leads to hyperplasia and thus increased activity within the bone marrow leading to systemic pyrexia
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These observations reinforced the diagnosis of pernicious anemia, confirmed by the presence of elevated intrinsic factor antibodies
