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Patients were assessed for pain intensity using the McGill pain questionnaire every two weeks from the point of randomisation, for a total of five time points

Splitting the dose or adding a second daily injection is not part of the clinical protocol and may not improve outcomes

More recently, a longitudinal study among 3,849 community-living older adults in Ireland found that low vitamin B 12 serum concentrations ( 258-601 pmol/L) (101)

However, it has been described that these substrates are produced in the cytosol to induce Ca 2+ release mainly from the endoplasmic reticulum or the extracellular space by activating Ca 2+ channels