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Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]

less commonly used in adults Partial enteral nutrition may supplement medical therapy and support nutritional status Total parenteral nutrition (TPN) indicated for severe malnutrition, short bowel syndrome post-resection, or surgical preparation 17

Injection site reactions : Localised redness, swelling, or discomfort at the injection site

This suggests that IcL induces different immune responses and activation levels in individual animals