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NQO1 plays a role in the redox reactions that create the reduced state of CoQ10, which is how it acts as an antioxidant.[ref] rs1800566 ( dbSNP) Research & references Genetic interactions with CoQ10 supplementation: CD36 gene: encodes a protein that affects the cellular uptake of CoQ10 rs1761667 ( dbSNP) Research & references CYP7A1 gene: a plant sterol and cholesterol-related gene rs3808607 ( dbSNP) Research & references NPC1L1 gene: cholesterol transporter that likely plays a role in the absorption of CoQ10 in the gut rs2072183 ( dbSNP) Research & references Lifehacks: In this section, Ill cover the different types of CoQ10 supplements (theres a bunch), safety considerations, and clinical trials that involve CoQ10

Again however, there is little evidence that these compounds would provide therapeutic benefits with conditions related to XO-derived RS production

If so, we speculate that there might be a variant COPI pathway that removes ER-resident membrane proteins from the ONM, allowing these proteins additional opportunities to reach the abundant ER in the gonad core