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Melatonin can be found as a bioavailable substance in many foods

The relationship between these metabolites and gut microbiota dysbiosis was also investigated (Fig

Moreover, the elevated levels of iron which can be essential during brain development, facilitates oxidative stress via iron-catalysed formation of ROS [14]

Currently, treatments based on copper metabolism in cardiovascular disease can encompass a wide range of options, including copper chelating agents [such as triethylenetetramine (TETA), tetrathiomolybdate (TTM) and disodium ethylene diamine tetraacetic acid (EDTA)], small-molecule inhibitors of copper chaperone proteins (such as DCAL50), copper ion carriers and natural antidote agents (Table II)