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A., Dupre, B
We hypothesized that the Nrf2-driven increase in expression of Slc7a11 and Gclc , and higher levels of GSH in KPK cells may result in export of glutamate in exchange for import of cystine (Figure 2A)
In the US, landmark initiatives such as the Orphan Drug Act (1983) 26 and the Accelerating Rare disease Cures program (2022) have promoted this mission by driving scientific innovation, regulatory flexibility and stakeholder engagement 27
[114] showed that the Nigrocin-PN with low hemolytic and cytotoxic activity has a broad-spectrum activity against multi-drug resistant pathogens
