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Specifically, the expression of Nrf2, HO-1, GSH, SOD, CAT, and GPX1 was significantly upregulated in the experiment group, while the levels of Keap1, Bax, and Caspase-3 were downregulated

Recent studies have identified new outcomes of hepatocellular injury, such as ferroptosis, a specific form of iron-dependent cell death that is closely associated with the pathogenesis of MASLD, given the livers propensity for iron metabolism and lipid peroxidation

6.2.2 Potential of active ingredients in future drug development The active ingredients of functional foods are not only used for dietary interventions but also hold great potential to become lead compounds for new drugs

Wabitsch M, Blum WF, Muche R, Heinze E, Haug C, Mayer H, Teller W