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In addition, busulfan can interact with the glutathione and sulfhydryl groups and disrupt the cellular redox equilibrium, resulting in increased oxidative stress in cancer cells (36, 37)

Urol J 5(4):255259 Safarinejad MR, Shafiei N, Safarinejad S (2011) A prospective double-blind randomized placebo-controlled study of the effect of saffron ( Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia

A long-term, randomised, double-blind, placebo-controlled study
