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In other words, the enzyme that destroys the natural painkillers and anti-anxiety brain chemicals called enkephalins is blocked by Semax, which has been independently proven to reduce anxiety and, therefore, likely decrease cortisol

Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43

Merighi et al., 2022)

However, using these medications on long-term had been associated with the occurrence of numerous adverse effects, including headache, insomnia, nausea, abdominal pain, dry mouth and liver injury (Ahn et al