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A good example is a review published in 2003 in Endocrine Reviews , in which the authors note the importance of [growth hormone] and IGF systems in normal skin homeostasis. They specifically mention the role that growth hormone plays in collagen synthesis and the effect that IGF has on skin cell proliferation

2018;30(4 Supple 1):2832
doi: 10.1016/S0167-7799(00)89017-4, [DOI] [PubMed] [Google Scholar] 27.Egbaria K, Weiner N

This is an enzyme that uses glutathione to lower oxidative damage in tissues, so selenium indirectly affects the antioxidative action of glutathione
