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Recent studies have also shown that accumulated uremic toxins can activate AhR during CKD progression, further inhibiting mitochondrial biogenesis by promoting the ubiquitination and proteasomal degradation of PGC1-, thus accelerating renal aging and fibrosis [308]
Urology 166 , 301302 (2022)

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Previous evidence reported a significant reduction in cerebrospinal fluid biotin in patients with multiple sclerosis and epileptics (63)
