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By integrating drugs targeting ferroptosis with other treatment modalities such as chemotherapy, immunotherapy, or targeted therapies, synergistic effects can be achieved, further augmenting treatment responses [318320]

Acetaldehyde, the primary metabolite of ethanol, is reintroduced into the intestinal lumen via bile

QS interference is an important anti-virulence mechanism by which clove phytochemicals can disarm pathogens without applying direct lethal pressure rather than killing cells, QS inhibitors attenuate collective behaviors that mediate virulence, biofilm formation, toxin production, and coordinated resistance mechanisms, and therefore may impose less selective pressure for conventional resistance (Figure 5)

Various studies and society guidelines report that approximately 527% of patients do not respond to or cannot tolerate first-line treatment [4, 15, 22, 29, 30, 32, 42, 97,98,99,100,101,102]