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One of the involved mechanisms may be GABA-mediated conversion of alpha cells to beta cells [137, 138]
Research into tirzepatide alone demonstrates robust weight loss outcomes: clinical trials showed average reductions of 2022% body weight over 68 weeks in patients with obesity
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doi: 10.1016/j.molmet.2021.101270 110 SheikhRShakerianSFatemi TabatabaeiSRHabibiA
