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When UA is activated by TLR4, its downstream signaling cascade (such as the IKK/IB/NF-B pathway) will be released, ultimately leading to induction of pro-inflammatory cytokines/mediators and tissue damage (Zhou et al., 2012)

Among the seven individuals initially diagnosed with VCD, four (57%) still exhibited the condition during the follow-up appointments, while three showed no further signs of impairment

Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis

Indeed, the hyperphosphorylated tau protein is known to destabilize the microtubules, which are involved in the elongation of neurites