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To illustrate, polymeric scaffolds with low crosslinking densities have high permeability which promotes the rapid release of the drug while high crosslinking density polymers lead to a sustained release

Over time, oxidative stress, inflammation, and disease risk increase

This knowledge coupled with the demonstration that some members of the 6-AH family bound with high affi nity to the hinge region of HGF led to the expectation that other active AnglV analogs, like 6-AH family members, could be expected to inhibit HGF dimerization and that the ability of an individual analog to bind HGF and inhibit HGF-dependent processes should be reflected in its capacity to attenuate dimerization

10.1016/j.brainresbull.2021.06.014 99 PetratF.RauenU.GrootH