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13,179 Free testosterone can be measured directly, or indirectly by means of a calculation from measurements of total testosterone and SHBG
109,146 (4) inhibits NLRP3, 147 a key inflammasome that activates pro-inflammatory cytokines, such as IL-1 and IL-18, which closely correlate with obesity and T2DM pathogenesis

Impaired energy production can result in hypoketotic hypoglycaemia (much like in primary carnitine deficiency)

A study of 179 diagnosed women, aged 20-75 years, found that being overweight was significantly associated with increased pain severity, reduced physical mobility, and poorer quality of life overall (22)
