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PloS One (2008) 3(11):e3731
A large number of mouse strains have been proposed and, according to McCarron et al., they can be categorized into three main groups: (i) Cftr null or knock out (KO) models
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This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance
