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This disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta that project to the striatum (Samii et al., 2004), and the early accumulation of -synuclein deposits in the cholinergic neurons of the basal forebrain

The ferrous-ferrozine complex exists in a 3:1 ratio of ferrozine to iron and is reported to have one of the highest molar absorptivity values (i.e., 27,900 M 1 cm 1 ) at 562 nm among other commonly used iron complexes (pH 4 to 9) (Stookey 1970)

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